First step in troubleshooting is to check whether the system and all participating devices are correctly configured. Some endpoints need to be registered using TLS to have SRTP available.
Ensure that the system is using the default settings for advanced options. If that is not the case, check that it is intentional.
If SIP devices are used and Best Effort is configured, check with System Status Application/SysMonitor how SRTP is negotiated and whether the device supports cap neg (can be checked by placing a call to device with both SRTP and RTP and then checking whether it responds with SRTP or RTP – if it is SRTP, cap neg is supported). If not, override device media security settings and configure Enforce or Disabled, as appropriate.
IP Office lines with Best Effort configured and both crypto suites are enabled can result in large call initiation messages on IP Office lines, ~ 5000 bytes. If the link is slow and/or the call rate is high it can have a negative impact. Consider using only one crypto suite or the lines' setting to Enforce or Disabled.
Some phones do not support RTCP (SRTCP); verify operation with SRTCP disabled.